Autoimmune diseases such as multiple sclerosis, lupus, and Crohn's disease affect millions of people worldwide-often with chronic progression, limited treatment options, and enormous individual burden. However, a new medical idea is gaining ground: the immune reset. This refers to the controlled reconstruction of the immune system through stem cell transplantation, gene editing, microbiome modulation, and targeted tolerance induction. This book illuminates the entire spectrum of modern immunotherapies - well-founded, interdisciplinary, and up to date with research as of 2025. It not only explains the medical basics and procedures, but also analyzes the latest clinical studies: from autologous stem cell therapy for MS to CRISPR-based T-cell modifications and peptide vaccines against autoimmunity. With a special focus on the new studies of recent years, the authors combine molecular precision with a systemic perspective - and make it clear that immunotherapy has long been more than just immunosuppression. A book for doctors, researchers, chronically ill patients - and anyone who wants to understand the immune system as a learnable, malleable system. Bremen University Press has published over 4,800 specialist books in various languages since 2005.