The early modern era produced the Scientific Revolution, which originated our present understanding of the natural world. Concurrently, philosophers established the conceptual foundations of modernity. This rich and comprehensive volume surveys and illuminates the numerous and complicated interconnections between philosophical and scientific thought as both were radically transformed from the late sixteenth to the mid-eighteenth century. The chapters explore reciprocal influences between philosophy and physics, astronomy, mathematics, medicine, and other disciplines, and show how thinkers responded to an immense range of intellectual, material, and institutional influences. The volume offers a unique perspicuity, viewing the entire landscape of early modern philosophy and science, and also marks an epoch in contemporary scholarship, surveying recent contributions and suggesting future investigations for the next generation of scholars and students.