Taking a "bottom up" approach to studying skin toxicology, this basic introduction to the principles and practice of dermal toxicology explores skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity, and in vitro alternatives.

Written by experts in the field, Principles and Practice of Skin Toxicology provides a "bottom up" approach to studying skin toxicology. It provides a clear outline of basic concepts, citing both historical and modern references, and contains a glossary of key terms for quick and easy reference. Arranged in a user friendly and logical sequence, the book covers the five main areas of dermatotoxicology: * Principles of skin absorption. Explains the factors influencing dermal absorption and associated methods of measurement. * Methods for assessing skin toxicity. An overview of both in vivo and in vitro approaches to testing, with particular emphasis on the validation and use of alternative test strategies. * Clinical and occupational skin toxicity. A basic introduction to dermatology and related applications central to understanding dermal exposure to chemicals. * Regulatory aspects. An overview of national and international legislation governing the safe marketing of pharmaceuticals, cosmetics and industrial chemicals. This book will be especially useful to scientists who are new to the area of dermal toxicology, as well as practitioners of toxicology, clinical researchers, and researchers in industry and academia.