Moe Horwitz is a Mafia hitman in Philadelphia who's tired of the cold, the snow, his lonely life, and killing men for money. Trouble is, he doesn't know how to get out of the life. Then the big boss in Philly sends him to Miami on the last passenger train with orders to a hit for the Miami boss. Moe quickly discovers that this job may well turn out to be far more than he, or anybody else, bargained for. Before he can make the hit, he has to recover $20,000 the victim owes the boss. However, when the victim tries to make him an offer Moe can't refuse, things take a sudden turn. Set in 1961, Last Train to Miami is filled with back alleys, broken deals, double-crosses, and death.