One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in the GI tract is to control the gastric residence time (GRT) via gastroretentive drug delivery system which will provide us with new and important therapeutic options. Controlling the residence time of a drug delivery system in a particular region of GI tract can utilize several approaches which include floating drug delivery system, high density system and mucoadhesive system. Helicobacter pylori bacteria are the causative agents of gastric ulcers.Certain conventional dosage forms fail to eradicate the bacteria from the stomach so a novel drug delivery system is the need of the hour for proper elimination of these bacteria locally as well as systemically. The gastro retentive systems can be the remedy and the substitute for the conventional dosage forms, which will have more rationality with excellent efficacy towards the eradication of H.pylori infections. The focus of the research work in this book is to formulate,evaluate and optimize the newer gastro retentive dosage forms of various approaches.