Nancy is admitted to the secure unit of a nursing home and Gene has to call upon his friends to help break her out: one his godson, a disgraced weatherman, and the other an ex-army marksman. On a tour bus, the band of misfits career towards Mississippi through a landscape of war, euthanasia, communism, religion and racism, and along the way discover the true meaning of love, family and - most important of all - friendship.