This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. Unique comparative treatment of oxidative stress and antioxidant defenses in vertebrates and invertebrates In one expertly edited and organized volume, Oxidative Stress in Vertebrates and Invertebrates brings together and analyzes the latest research findings in the field in order to present our current state of knowledge. The text bridges the gap between basic science and clinical studies, making it possible for readers to apply basic science to better understand and manage chronic diseases associated with oxidative stress. Moreover, it provides a unique comparative treatment of oxidative stress and antioxidant defenses in vertebrates and invertebrates, examining basic mechanisms, biomarkers, and oxidative stress-mediated chronic diseases. Featuring contributions from leading experts in oxidative stress-mediated cell signaling, the text is divided into two sections. Part I, Oxidative Stress in Vertebrate Systems, explores such topics as: * Generation of reactive oxygen species and their role in cell survival and suicide * Oxidative stress and neuroinflammation in Alzheimer's disease and Parkinson's disease * Comparison of oxidative stress in aging between vertebrates and invertebrates Part II, Oxidative Stress in Invertebrate Systems, explores such topics as: * Effect of oxidative stress on insect endocrine control * Innate immune system in airway epithelial cells of Drosophila * Oxidative challenge and redox sensing in molluscs The final chapter provides a perspective on emerging research and directions for future investigations. Throughout the text, readers will find plenty of figures and line drawings of signal transduction pathways that illustrate key concepts and processes. Extensive references to the primary literature plus a bibliography facilitate further research into each topic. This text is recommended for biochemists, neuropharmacologists, toxicologists, and clinicians who need a state-of-the-science understanding of the mechanisms of oxidative stress in vertebrate and invertebrate systems.